RESUMO
Background: In Colombia, several species of Buthidae scorpions belonging to the genera Centruroides and Tityus coexist, and their stings are considered life-threatening to humans because of their venom neurotoxins. Despite previous studies focusing on neurotoxins from these scorpion genera, little is known about the enzymes present in their venoms and their relationship with whole venom toxicity. Methods: Here, using proteomic and biochemical protocols the enzymatic activities of the venoms of three Colombian scorpion species, C. margaritatus, T. pachyurus, and T. n. sp. aff. metuendus, were compared to establish the presence and absence of enzymes such as phospholipases, hyaluronidases, and proteases that could be related to venom toxicity. Results: C. margaritatus was positive for hyaluronidases, T. n. sp. aff. metuendus for proteases, and T. pachyurus exhibited activity for all three mentioned enzymes. Conclusion: This information provides valuable insights into the specific enzyme diversity of each species' venom and their potential role in venom toxicity, which could contribute to the development of better treatments and prevention strategies for scorpion envenomation.
Assuntos
Venenos de Escorpião/enzimologia , Venenos de Escorpião/toxicidade , ColômbiaRESUMO
El avance en las técnicas de reanimaciónj eenl desarrollo oe nuevos meácamentos para el soporte inotrópico ha permitido mejorarla supervivencia luego de un paro cardiorrespiratorio. Sin embargo, ,ada la frecuencia a importancia de lal secuelas neurológicas que se esocian a este evento, las lesiones del sistema nervioso central persisten como una de las afeeciones asociadad más importantes. Foresta taZón, lol indicadores de pronóstico neurológicojuegan un papel fundamental en el manejo de estos pacientes. Esta es una revisión del papel de la resonancia magnética con espectroscopia en la evaluación, el manejo y ja predicción de los resultados neurológicas a largo pla^o después se lesiones del sistema nervioso central, como las que pueded ocurrir durante un paro cardiorrespiratorio.
The advance in the reanimation techniques andin the devekpment of new medicines for inotmpic support have made itpossible to improve the survival a after a cardiorespiratory arrest. Hotuever, given thefrequency and importame of the neurological ssquel that are associated to this svent, the injuries of fhe central nervous sjstem persist as one of the most important associated morbidities. For this reason, the indicators of neurological prognosis play a fundamental role tuith the management of thesepatients. This is the review of the role play ed by magnetic resonance spectroscopy in tht evaluation, management andprediction of the long term outcome after injuúes to the central nervous system like those that may occur during a cardiorespiratory arrest.